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Resources Hub

As your partner in Drug Discovery, Biortus’s technical series covers the latest and best practices in Protein Expression, Protein Purification, Membrane Proteins Purification, Assay Analysis and Screening, X-ray Chromatography, and Cryo-EM technology, from target determination to pre-clinical, helping you scale your business. 

Protein Expression and Purification

At Biortus, we mainly utilize three widely used expression host systems, bacteria, insect cells, and mammalian cells, for recombinant protein expression. We continue to develop new techniques, such as new affinity tags, new expression systems and membrane protein purification methods for a better protein production.   

Biortus Protein Expression Platform (pdf)

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Finding the right expression system (pdf)

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Biortus Protein Purification Platform (pdf)

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Biortus Membrane Protein Purification (pdf)

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Assay and Screening

Compound screening against a drug target is a vital step in early stage drug discovery. Biortus has an extensive collection of testing equipment that allows us develop of many kinds of biochemical assays,   biophysical assays, and cell-based assays, for hit identification to lead generation. 

Biortus Hit Discovery and Lead Evaluation Services (pdf)

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X-ray Crystallography

 Biortus provides X-ray based high resolution crystal structures for Epitope Mapping, protein engineering, and structure-based or  fragment-based drug discovery. With the in-house instruments and access to Synchrotron data collection facilities worldwide, we can provide fast turnaround and high-throughput crystal screening and high-resolution data collection. 

Biortus X-ray Crystallography Platform (pdf)

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Cryo-EM

Our cryo-EM team has a combined experience of over 35 years and has published many cryo-EM related research in high-impact journals.  Syncretizing our cryo-EM expertise with access to high-end cryo-EM  equipment, Biortus is aspired  to becoming the pioneering CROs in  providing high resolution cryo-EM structures for our clients.  

Biortus Cryo-EM Platform Introduction (pdf)

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First Cryo-EM Structure of the Membrane Protein GLRA3 at 1.82 Å Resolution (pdf)

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